Can depression cause irregular periods? Pristyn Care Asked: April 15, 2021In: Irregular Periods Yes. Hypothalamic amenorrhea is the condition in which women suffer from irregular periods due to depression. Due to stress and anxiety, the body produces cortisol in excess amounts that can reduce the production of progesterone and estrogen. Studies conclude that women suffering from mental health problems are likely to suffer from irregular periods as the normal hormonal balance is disrputed that leads to delay in menstrual cycle. April 15, 2021 Pristyn Care 0 people found this helpful Was this answer helpful?