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Why Does IVF Sometimes Fail? Causes & Prevention

3 weeks ago

IVF treatment costs around 1 lakh, but I’ve heard that the first cycle often fails. What are the reasons IVF can fail, and how can we avoid it?

Asked By Mayank | Male | Age 35

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3 weeks ago

Answers (1)

Dr. Mannan Gupta

MBBS, MS-Obs & Gyne | 15 Years Experience Overall

Answered 28/11/2025

The success of IVF is similar to natural conception. Even if both the female and male reproductive systems are healthy, pregnancy does not happen every month. Likewise, IVF does not guarantee 100% success.

If everything is ideal healthy partners, good egg and sperm quality, and a properly prepared uterus lining around 60–70% of couples may succeed in the first attempt, and up to 95% succeed within three attempts. Several factors affect IVF success.

Age is crucial; 25–35 is considered the ideal reproductive age, and beyond that, complications increase, reducing success rates. Egg and sperm quality, as well as the uterus lining (endometrium), play major roles.

The quality of IVF medications and injections is also important, as these hormones stimulate egg production and are often imported and expensive. The lab conditions where the embryo develops outside the body are critical, because the uterus environment must be accurately replicated using high-tech equipment and specialized media.

Additionally, the skill of the doctor performing the procedures and embryo transfer, along with proper testing and monitoring, significantly impacts the outcome.

While IVF is not a guaranteed one-step solution, with careful planning, skilled doctors, and repeated cycles if needed, the chances of success are very high. The cost is high because creating the perfect environment to develop an embryo outside the body is a complex and scientific process.

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