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Zerodol SP Uses

Zerodol-SP tablet features a combination of Aceclofenac, Paracetamol, and Serratiopeptidase and belongs to the non-steroidal anti-inflammatory drug category. It is typically prescribed to Reduce the pain and inflammation in the bones or muscles that has occured as a result of:

Bone or soft tissue injury


Rheumatoid arthritis

Osteoarthritis or ankylosing spondylitis.

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How it Works?

Zerodol-SP is a combination of three salts; Aceclofenac, Paracetamol, and Serratiopeptidase, that collectively combat pain and inflammation. Here's how this medicine works:

Aceclofenac: Aceclofenac blocks the action of cyco-oxygenase, an enzyme that causes pain and inflammation in the damaged tissue. Aceclofenac works by blocking the action of an enzyme known as cyclo-oxygenase (COX) which causes pain and swelling in the injured or damaged tissue.

Paracetamol: Paracetamol functions as a mild analgesic i.e., a pain reducer, and antipyretics i.e., a fever reducer to support and enhance the pain-relieving effect of aceclofenac.

Serratiopeptidase: Serratiopeptidase works by breaking down fibrin (a protein) which forms as a result of blood-clotting at the site of the injury. It causes the fluids to become thin and allow smooth fluid drainage in the affected tissue.

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Man taking Zerodol SP tablet

Direction for Use

Zerodol SP should only be taken after consulting a doctor.

Take this medicine as a whole with water. Make sure you do not crush, break, or chew the tablet.

Additionally, it must be consumed in amounts prescribed by the doctor.

Do not consume it more than prescribed limit to manage pain.

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Zerodol SP Side Effects

Zerodol SP is safe to consume and does not cause any complications after consumption. However, in some cases, people may experience the following side-effects:


Loss of appetite

Stomach upset

Stomach Pain



Safety Advice for Zerodol SP

Safety Advice Alcohol


Avoid consuming alcohol while taking Zerodol SP as it may affect your liver adversely and cause other side effects as well.

Safety Advice Pregnancy


If you're pregnant or breastfeeding, do not take this tablet without consulting your doctor.

Safety Advice Driving


Since Zerodol SP can cause dizziness, avoid driving after consuming this medicine. Anyone with liver or kidney issues must also be cautious while taking this medicine

Drug interactions

Zerodol drug interactions can lead to serious complications. Therefore, if you're taking Zerodol SP, make sure you avoid taking the following medicines:
  • Other medicines with paracetamol or Aceclofenac composition.
  • Water pills
  • Medicines for heart failure-Lithium and Methotrexate
  • Cyclosporine and tacrolimus
  • Steroids and pain-relief medicines such as Aspirin.
  • Blood thinners such as Warfarin and Coumarin
  • Levofloxacin and Ciprofloxacin
  • Diabetes medicine
  • Phenobarbital, Carbamazepine, Phenytoin and Clonazepam.

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