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Anti Mullerian Hormone (AMH) Test, Normal Range & Diagnosis

Understand what is amh test for female and how it impacts fertility. Get in touch with the fertility experts at Pristyn Care to discuss your condition in detail and effective fertility-related personalised solutions.

Understand what is amh test for female and how it impacts fertility. Get ... Read More

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What is Anti-Mullerian Hormone?

Anti-Mullerian Hormone, or AMH, is a protein that is generated by the testicles in men and the ovaries in women. Also called Mullerian-inhibiting hormone(MIH), AMH helps in the development and functioning of the reproductive organs in both men and women. Testicles are the glands that produce sperm & male hormones, and ovaries are the glands that produce female hormones and eggs. Granulosa cells in ovarian follicles secrete AMH, which gives information on a woman’s reproductive health. AMH levels in women represent the ovarian reserve, or the quantity of eggs left, and decrease with age until menopause. It affects sperm production and sexual development in men.  

AMH functions differently in men and women, and the normal range of AMH varies according to age and sex. Measurement of AMH levels can reveal details regarding a range of reproductive health issues. Anti-Mullerian hormone test is conducted to determine the AMH levels in blood. An AMH blood test is mostly performed on women to evaluate their reproductive potential. It can also help in the diagnosis of PCOS, ovarian tumours, and the infertility-related treatment planning.

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Why is AMH Test Essential?

During the first few weeks of pregnancy, both male and female babies have a set of tubes or ducts known as MĂ¼llerian ducts. Usually, the testicular tissue of male infants produces large amounts of AMH. The AMH causes the MĂ¼llerian ducts to contract and promotes the growth of male organs. High levels of AMH are found in male children until puberty, after which they start to fall. 

 

Unborn female babies have low levels of AMH, causing the mullerian ducts can develop into the uterus, fallopian tubes, and upper vagina. AMH levels are extremely low in female children. Ovarian follicles start producing more AMH at puberty. The ovaries contain tiny sacs called follicles that hold immature eggs.

 

Higher levels of AMH indicate a greater quantity of eggs in the ovaries of females in the reproductive age. Females produce fewer eggs as they become older, which lowers AMH levels. AMH levels fall to zero at menopause, which indicates the absence of eggs.

Does AMH Levels Help in Determining the Egg Quality?

Although AMH levels are a reliable indicator of egg quantity, it doesn’t give much information about the quality of eggs in the ovaries. For women in their mid-30s, egg quality normally decreases even when the AMH levels are within the normal range. It indicates that the women with high AMH levels may also experience infertility due to deteriorating egg quality. However, younger women with lesser amounts of AMH may still produce high-quality eggs. Therefore, while AMH levels are more strongly correlated with the number of eggs, age continues to be the key factor influencing egg quality. 

AMH Test Uses: When Should You Consult a Doctor

  1. Addressing Infertility in Women

AMH tests are often used to determine a woman’s infertility. Although the test can not determine fertility, but helps in the decision-making process for infertility treatments. For instance, it can be used to assess a woman’s potential responsiveness to infertility treatment therapies and the number of eggs present in her ovaries. Although the ovaries normally only release one egg per month, IVF procedures help in preparing several eggs. The results of the AMH tests are helpful in determining the necessary dosage of IVF medications.

 

  1. Menopause

The AMH test can not predict when a woman will experience menopause. However, it may reveal if the person is approaching menopause or has already begun it, particularly early menopause. The AMH test findings can also be used to screen for early (before the age of 45) and premature (before the age of 40) menopause because both egg count and AMH levels decline closer to menopause.

 

  1. Identifying Ovarian Issues

 There may be innumerable applications for the AMH test in women. This test can be used to diagnose conditions like PCOS (polycystic ovary syndrome) or even some types of ovarian cancer.

 

  1. AMH Levels in Infants and Children

Additionally, children’s medical issues can also be diagnosed with the help of an AMH test. For instance, AMH levels are usually low during puberty. During puberty, high AMH levels may notify doctors of underlying issues.

 

  1. Ovarian Reserve

The number of eggs in your ovaries is known as your ovarian reserve, and it normally decreases with age. Although an AMH test can determine the quantity of your ovarian reserve, it cannot determine the health of your eggs or your chances of becoming pregnant.

 

Likewise, AMH test results can help in identifying the cause of ambiguous genitalia, a condition in which it is impossible to discern whether an infant’s external genitalia are male or female.

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When to do AMH test?

Unlike other fertility diagnostic tests, the AMH test can be conducted at any time of your menstrual cycle. As it is largely produced by the immature follicles, the values don’t fluctuate much. Your doctor will conduct a small blood test and send it to the lab. The results are usually given within a week. 

 

Medical professionals may recommend AMH tests to be done in the following situations.

 

  • PCOS symptoms, such as irregular or no periods, excessive facial hair, male pattern baldness, etc. 
  • Fertility issues or when the female is undergoing an IVF procedure or any other fertility treatments
  • Being treated for certain types of ovarian cancer

AMH Tests: How to Prepare?

  • Dietary and Fasting Tips: You can eat and drink as usual, and there is no need to fast.
  • Medication: Inform your doctor about any medications or hormonal treatments you are taking, as they may affect the outcome.
  • Timing: You can take the test on any day of the menstrual cycle.
  • Hydration: To ensure a smooth blood draw, stay hydrated.

AMH Test Procedure

  • Preparation Process: A medical practitioner applies an antiseptic to the puncture site.
  • Blood Sample: A blood sample is taken by inserting a needle into the vein.
  • Final Step: After removing the needle, the site is bandaged.
  • Laboratory Analysis: The sample’s AMH levels are examined and analyzed.

 

When the needle enters or exits your body, you could experience a slight sting. Usually, results are ready in a few days.

AMH Test Results Explained: AMH Levels By Age

AMH levels are measured in nanograms per milliliter (ng/mL) units and naturally fluctuate with age. An overview of AMH levels by age is shown below, indicating what may be regarded as amh test normal range or suggestive of good fertility.

 

AMH Levels By Age Chart 
Age(years)  Low(ng/mL)  Normal(ng/mL)  High(ng/mL) 
Under 25  Less than 1.02 1.2 – <5.0 Higher than 10
26-30 Less than 0.69 1.2 – <5.0 Higher than 10
31-35 Less than 0.36 1.2 – <5.0 Higher than 10
36-40 Less than 0.18 1.2 – <5.0 Greater than or equal to 5
41+ Less than 0.01 1.2 – <3.0 Greater than or equal to 3

What Does Having a High or Low AMH Indicate?

  • Low AMH levels

This could be a sign of low ovarian reserve(also known as ovarian reserve). It indicates that your ovaries have less follicles than the majority of people your age, and may cause a below average IVF outcome. Although it is relevant for IVF, where specialists will strive to extract as many eggs as possible in each round to increase your chances of success, but it has little effect on your chances of getting pregnant naturally.

  • High AMH levels

This could be a sign of polycystic ovarian syndrome (PCOS), a hormonal imbalance that can make getting pregnant challenging. Additionally, it could mean that you are more susceptible to ovarian hyperstimulation syndrome(OHSS) from ovarian stimulation during IVF. If you have high oestrogen levels prior to the egg retrieval process and/or had a large number of follicles (more than 20), you may develop OHSS, an uncomfortable and potentially hazardous condition.

Factors affecting AMH outcome

  • Age: As people age, their AMH levels normally decrease.
  • PCOS: Women with PCOS may have higher levels.
  • Ovarian Surgery: Operations that alter ovarian tissue have the potential to lower AMH levels.
  • Medication: Hormonal therapies can change AMH values.
  • Lifestyle Factors: Obesity and smoking have a detrimental effect on AMH levels.

Fertility Treatment for High AMH Levels

  • Ovulation induction

You may have issues with ovulation if PCOS is the cause of your high AMH level.  If so, you can ovulate and release a mature egg with the aid of hormonal injections. Additionally, you can schedule your sexual activity to ensure a successful pregnancy. If your partner’s sperm are unhealthy, you can opt for IUI (Intrauterine Insemination).

  • IVF (In Vitro Fertilisation): 

Ovulation induction won’t work for you if a substantial ovarian reserve is the cause of your high AMH level. Ovarian induction can also raise the possibility of multiple pregnancies and other difficulties, while also encouraging the development of multiple eggs.

 

Therefore, you can opt for IVF, in which only one or two healthy embryos are placed into the uterus after the eggs are extracted and fertilised in a lab.  It increases the successful pregnancy rates and reduces the likelihood of multiple pregnancies.

Another choice for women with elevated AMH levels is egg freezing. Your eggs will be kept at freezing temperatures for preservation. These eggs can be used to conceive in the future.  

  • Changes in lifestyle

In addition to fertility treatments, leading a healthy lifestyle is a significant factor that affects fertility.  Adhere to the following lifestyle adjustments in your day-to-day life for a healthy pregnancy: 

  • Maintaining a healthy weight
  • Eating wholesome meals
  • Managing stress levels

Frequently Asked Questions

What is a good amh level to get pregnant?

A good AMH level for pregnancy is generally considered to be between 1.0 and 4.0 ng/mL, and it indicates a healthy ovarian reserve. However, AMH is just one factor in assessing fertility, and several other factors, like age, quality of eggs, etc., play a significant role, too. Therefore, always consult a professional for personalized advice.

How to improve anti mullerian hormone levels?

You must concentrate on maintaining a healthy lifestyle through consuming a balanced diet rich in antioxidants and omega-3s, a consistent exercise schedule, getting enough sleep, and managing stress levels. Avoiding smoking, consuming excessive alcohol, and environmental toxins is also important to improve AMH levels. For a personalised care routine, consult the experts at Pristyn Care.

Is it possible to get pregnant with a high AMH level?

As mentioned above in the article, AMH(egg count test) levels indicate the number of eggs(ovarian reserve), and not the quality of eggs. To understand, how much amh is required for pregnancy, you need to learn that high AMH levels signifies a good ovarian reserve and is beneficial in assisted or natural conception. However, these can also be associated with PCOS, and other infertility-related issues. Therefore, for a clear understanding, you must consult a specialist at Pristyn Care. 

How to check amh levels?

You need to undergo a simple blood test, performed by a healthcare professional. They will blood sample from your arm and is then sent to the laboratory for analysis. It can be conducted on any day of the menstrual cycle and no special preparation is required before the test.

What are the symptoms of low amh in females?

Difficulty in conceiving, irregular or no periods, early menopause symptoms like hot flashes and fatigue are a few of the common signs of low AMH and necessitate a low amh treatment.

What are considered to be the normal amh levels in females?

Anti-mullerian hormone levels indicate the ovarian reserve and naturally decline as women age. Although the normal anti mullerian hormone range varies by age, a range of 2.0–4.0 ng/mL is considered to be normal. Â