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Male Infertility

What is Male infertility?

Any health condition in a man that lowers his chances of getting his female partner pregnant is known as male infertility. Having a baby is generally a natural and simple process. But unfortunately, there are couples for whom the experience can be tough and it can be difficult for them to conceive. Approximately, 13 out of every 100 couples fail to make their partners pregnant even with unprotected sex. According to medical reports, 1 in every 7 couples is infertile, which means for some reason or the other, they have not been able to conceive a child, even after trying unprotected sex for more than a year. In half of these cases, male infertility is the major contributing factor for the infertility issue in the couple.

What happens in male infertility?

A man plays a significant role in making his female partner pregnant since the pregnancy depends upon the quality and the quantity of his sperm. In case the male fails to produce the required amount of sperm or the sperm is of poor quality, it may be impossible for the male to impregnate his female partner. If you and your partner are trying to conceive a baby but failing to do so even after trying unprotected sex for more than a year, you should check with a urologist or an infertility specialist.


  • Sperm Disorders (not fully grown/ oddly shaped/ low in numbers/ do not move the right way)
  • Hormones
  • Varicoceles
  • Retrograde Ejaculation
  • Immunologic Infertility
  • Obstruction
  • Medication
  • Undescended testicles


  • Problems with sexual functioning
  • Inability to smell
  • Pain and swelling in the testicle area
  • Gynecomastia (abnormal growth in the breast tissues)
  • Sperm count lower than normal
  • Decreased facial hair due to hormonal abnormality


  1. Semen Analysis

Semen analysis is a routine test for male infertility that is done in labs. The test helps in determining the exact cause of male infertility. In most cases, the test is done twice to find out the exact cause. The semen is usually collected in the lab. The man is required to masturbate and provide his sperm in a sterile cup. Once the semen is collected, the sample is sent for evaluation. During the evaluation, the doctor studies your sperm count, the concentration and movement of the sperm, and the structure of the sperm. The sperm quality tells the doctor about your ability to help a woman conceive.

If the produced sperm turns from pearly gel into liquid within 20 minutes, the semen is considered to be normal. If this does not happen, something is likely wrong with the man’s sex glands and seminal vesicles.

If the semen analysis shows no sperm at all or low sperm count, it may indicate that the male is permanently infertile. In such a case, the doctor may either proceed with further tests or may recommend you consult with an infertility specialist.

  1. Transrectal ultarsound

In many cases, men are asked to undergo a transrectal ultrasound to diagnose their infertility issues. During the ultrasound, sound waves bouncing off an organ are used to get an image of the organ. A probe is placed in the rectum. The probe beams sound waves to the nearby ejaculatory ducts. During the ultrasound, the healthcare provider can find out if there is any abnormality or blockage in the seminal vesicles or the ejaculatory duct in the man.

  1. Testicular biopsy

If the semen analysis shows a very low sperm count or no sperm at all, the doctor may proceed with a testicular biopsy. Testicular biopsy is done under either local or general anesthesia. During the procedure, a small cut is made in the male’s scrotum. The test can be done at a clinic or lab. The doctor first numbs the scrotal area and then takes a small piece of tissue from each testicle. The tissue samples are then studied under a microscope. The testicular biopsy serves two purposes – it helps the doctor determine the cause of infertility. Additionally, if there is any semen sample in the tissue, it can be used in assisted reproduction.

  1. Hormonal profile

In this test, the doctor checks your hormones. Once the detailed hormonal profile is received, the doctor can understand how well your testicles make sperm. The test can also help rule out other problems. In the hormonal profile test, the patient is required to give a blood sample. The doctor runs a series of tests with that blood sample to obtain a complete hormone profile. The doctors evaluate the levels of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Testosterone, Prolactin, and Sex Hormone Binding Globulin (SHBG) to test infertility in the man.

Test of Male Infertility

Grades of sperm motility

Sperms are those which swim forward fast in a straight line – like guided missiles.

Complications of male infertility

The major complications of male infertility is often psychological. The inability to conceive a child can lead anyone to stress and relationship difficulties. The condition often hurts the male ego which further creates rifts and complications in his personal relationship with his partner and other family members.

  • Prevention of male infertility

    Prevention of male infertility

    Prevention of male infertility

    There is no way you can prevent infertility caused due to physical deformities in cases where the vas deferens are missing. If the infertility is a result of addictions, infections, or other reversible conditions, timely treatment can help a male treat his infertility issues. Infertility issues that are caused due to lifestyle0related problems can be prevented or managed with proper physical care. Below mentioned are some of the lifestyle issues which can be helpful in preventing male infertility.

    • Maintain a healthy body weight – Obesity and overweight have been directly associated with infertility problems. To prevent obesity from contributing to infertility issues, it is important for the man to maintain healthy body weight.
    • Maintain an optimum testicular temperature – Wearing tight-fit clothes for a long time can affect blood flow to the genitals and can also alter the testicular temperature. The higher testicular temperature has been medically associated with altered sperm production.
    • Quit alcohol, smoke, and drugs – Substance abuse can significantly disturb the functioning of the biological process of the body. Excess consumption of any form of intoxicating substance can ruin your reproductive health.
    • Keep a check on your diet – You are what you eat. Most people are not aware of this, but one cannot deny the fact that a person’s reproductive health is very closely associated with what the person eats in a day. If you want to enhance your sperm production, add a lot of vitamin C, zinc, and healthy nutrients to your system.
    • Swear by the benefits of exercise – Exercise is the best way to ensure a healthy immune system. If you are not physically active, your body is likely to become more susceptible to inflammations and infections which might contribute to infertility down the line.
    • Keep gadgets away from your genitals – electronic gadgets like laptops and mobile phones emit low-level radiation which can affect sperm production. To prevent infertility problems, you need to make sure that you do not keep mobile gadgets and laptops in your pocket for a long time.
  • Myths and facts about male infertility

    Myths and facts about male infertility

    Myths and facts about male infertility

    Myth 1 – Infertility is not a man’s problem.

    Fact – If a couple fails to conceive a child, in most circumstances, the female is held responsible or incapable of bearing a child. This is a very common social structure in India. Most people fail to understand that the problem could equally lie in the man. Globally, infertility affects up to 15 percent of couples. In almost half the cases,  infertility is caused due to some reproductive and genital issues in males. While it is easily assumed that infertility is a female problem, the fact that male fertility has a role to play in making a woman pregnant often goes unnoticed and unattended.

    Myth 2 – Boxers can manage sperm health, it’s better than briefs.

    Fact – There is an age-old belief that boxers are better than briefs in managing sperm health. Most people believe that boxers are better than briefs for reproductive health since it prevents the temperature of the scrotum that can be caused due to wearing briefs for ling hours. But there is no medical evidence to support this age-long belief.

    Myth 3 – The ability to father a child has nothing to do with the man’s age.

    Fact – Age has a direct correlation with a man’s age. After a man reaches 40 years of age, his sperm quality and quantity begin to decline. Unlike women, men do not go through menopause and hence they do not completely lose the ability to produce sperm. But sperm production definitely goes on a downward dip which is a major cause in many couples for their inability to conceive.

    Myth 4 – If the ejaculate looks normal, the sperm is of optimum quality.

    Fact – Most of the ejaculated fluid is not sperm. Sperm is microscopic and the motility and quality can only be evaluated after a thorough test. The only way to determine the quality of the sperm is by doing a sperm analysis from trained lab technicians.

  • Male celebrities who struggled with infertility

    Male celebrities who struggled with infertility

    Male celebrities who struggled with infertility

    Jimmy Fallon – Jimmy Fallon, the former SNL star and current host of The Tonight Show had struggled with infertility issues for quite a long time. Later, he and his partner Nancy Juvonen succeeded with a daughter. Jimmy Fallon has been open with his issue and went on to advise on TODAY,


    “If there’s anybody out there who is attempting and they’re simply losing expectation, simply hold tight.”


    Mark Zuckerberg – Facebook founder, Mark Zuckerberg opened up to the world about his struggle with infertility. After a long period of disappointment, the couple was blessed with a baby girl in 2015. In a Facebook declaration, Mark shared that they had experienced three miscarriages. He trusted the post would help many couples struggling to become parents not lose hope and supported an exchange about fertility issues. They are currently guardians of two kids, Max and August.

    Hugh Jackman – Celebrated Hollywood actor, Hugh Jackman is one of the very few male celebs who has come out and has been openly speaking about his struggle with infertility. The actor has always been honest and candid about what the couple has gone through.

    Gordon Ramsay – Gordon Ramsay is yet another celebrated figure who has been very vocal about his infertility issues. The celebrated chef had struggled with major infertility issues. Reports that surfaced on the internet said that his wife Tana had polycystic ovarian syndrome (PCOS) but Gordon Ramsay suffered fertility issues too. He was diagnosed with low sperm count, which made it very tough for his wife to conceive a baby, who was already dealing with PCOS.

When to consult a doctor for male infertility?

One should contact a doctor if one is unable to conceive a child after a year of frequent, unprotected sex or if one experiences any symptoms and signs of male infertility. A man should also consult a specialized urologist if he notices any form of abnormalities in his scrotum or testicles such as swelling in any veins in the scrotum or unusual sensation and swelling in testicles. If the man experiences any difficulty in maintaining an erection or ejaculating, he should consult with a urologist at the earliest to rule out potential complications.

Questions to ask your doctor

Am I the right candidate for the treatment?
What are the chances that I can father a baby after the treatment?
Can my partner accompany me during the procedure?
Is the complete treatment confidential at your clinic/ hospital? Will others get to know about my problem?
Can you give me a clear picture of the expenses so that I can prepare accordingly?
Is your team trained and efficient enough to help me in the whole process?
What if we do not succeed? Is there any alternative?

Treatment options & cost

  1. Anejaculation

Anejaculation is when there’s no semen. It’s not common, but can be caused by:

  • spinal cord injury
  • prior surgery
  • diabetes
  • multiple sclerosis
  • abnormalities present at birth
  • other mental, emotional or unknown problems

Drugs are often tried first to treat this condition. 

  1. Congenital Adrenal Hyperplasia (CAH)

CAH is a rare cause of male infertility. It involves congenital problems in certain enzymes. CAH causes abnormal hormone production. CAH is most often diagnosed by evaluating the steroid level in the blood and urine. CAH can be treated with hormone replacement.

  1. Retrograde Ejaculation

Retrograde ejaculation is a condition in which the semen flows back instead of going out of the penis. It can be caused by:

  • prostate or bladder surgeries
  • diabetes
  • spinal cord injury
  • anti-depressants
  • certain anti-hypertensives
  • medications used to treat prostate enlargement (BPH)

Retrograde ejaculation can be treated with drugs.

Recovery after male infertility treatment

Recovery after male infertility treatment

The recovery process and the timeline solely depend on what treatment method. If the treatment is medications, there is nothing that the patient would need to recover from. However, male infertility treatment with medications is a long process and the patient might require to continue the medications for several weeks and months. For a patient who undergoes surgical treatment for male infertility, such as varicocele surgery, the patient may need a month or two or even longer to recover, depending upon how severe was the health condition and how major was the surgery. Recovery after testicular or epididymal sperm retrieval depends on the method used. Recovery time can range from a few days to a week. During the recovery process, the patient will have to avoid strenuous activities. The patient will be advised to wear a jockstrap until full recovery, take medicines prescribed by the doctor without fail and use ice packs at the surgical site to heal better from the surgery. Most men after sperm retrieval can return to work within 24 to 48 hours. However, for some others, it may take a longer time to recover completely.

Recovery after male infertility treatment

Video testimonial - by patient

Video on the disease and treatment - by Pristyn Care doctor

Latest research on male infertility

  • Latest research on male infertility

    Trends of male factor infertility, an important cause of infertility: A review of literature 

  • Latest research on male infertility

    New ray of hope for male infertility patients

  • Latest research on male infertility

    New method could overcome genetic male infertility 


What health problems can cause male infertility?

There are several health problems – from kidney disease to testicular cancer – that can cause male infertility. “Whole-body” health problems and metabolic disorders, and ordinary fevers and infections can also alter sperm growth. Genetic problems such as cystic fibrosis may result in no sperm in a man. Not many people are aware of this, but there are several health problems that can cause male infertility.

Can an infertile man change to being fertile?

With infertility treatment at an early stage, the exact issue in the man can be treated to a large extent. But, the effects of infertility can be different from man to man. Only your doctor can say the answer to this question after proper diagnosis.

How can a man know if he is infertile?

Following are some of the common symptoms which can tell that a man is infertile – abnormal change in his hair growth, low sexual desire, swelling, lump or pain in and around the testicles, problems having an erection, and small and firm testicles.

Who is the right candidate for fertility preservation?

Fertility preservation is an option for a man who:

  • Has an autoimmune, genetic, or hormonal disorder
  • Has experienced trauma
  • Has a high-risk profession such as military deployment
  • Is diagnosed with cancer at a young age
  • Has low sperm count for no known reason
  • Wants to have children in the future
  • Has a condition where the sperm transports out of the body
Where will be the sperm collected?

The sperm will be collected at a licensed laboratory, fertility centre, sperm bank or a licensed fertility hospital. You should not go to any other place apart from these options to donate your sperm.

What is the cost of sperm retrieval and storage?

The cost of sperm retrieval is never definite can vary depending upon certain factors including:

  • If the retrieval is done in an office or an operating room
  • The procedure type and how long it takes. For PESA, the cost may range from INR 30,000 to INR 35,000. The cost of MESA is comparatively higher and can go up to INR 1,00,000.
  • Whether the sperm would be used now or in the future and for how long.
What if I have to move to a different city or state?

If you move to a different city or state during the course of your treatment or after sperm retrieval, you can work with sperm banks to move your sample to someplace else.

I have diabetes. Should I freeze my sperm?

If your ejaculate volume is decreasing and you’re still young, talk with a urologist about fertility preservation.

How is the health of semen evaluated?

The health of semen is evaluated through a semen analysis by an andrologist. The health of the semen shall be evaluated on the basis of three prime factors – count, motility and morphology.

What is a normal sperm count?

The normal range for the number of sperm per milliliter spans from 15 million to 100 million. Sperm counts below 10 million are considered poor while a sperm count of 15 million or more may be fine if motility and morphology are normal. A complete lack of sperm occurs in about 10-15% of men who are infertile.

Can cigarette smoke affect sperm quality or quantity?

Yes. Research shows that routine smoking affects sperm in many ways. It causes sperm cells to be smaller and slower. It also harms the DNA of sperm. Smoking can also affect the seminal fluid ejaculated with sperm.

Statistics and data on male infertility


  • Infertility affects an estimated 15 percent of couples globally, amounting to 48.5 million couples.
  • Males are found to be solely responsible for 20-30 percent of infertility cases and contribute to 50% of cases overall.
  • Male infertility is a factor in 30 – 50 percent of couples trying to get pregnant a second time.
  • 81 percent of couples having difficulty getting pregnant a second time receive a diagnosis of varicocele as the primary factor in infertility.
  • Varicocele is directly linked to sperm damage-causing infertility in most males.
  • Timely treatment of varicocele can improve chances of pregnancy from 30 – 50 percent.
  • 60% percent of men will have improved semen quality after undergoing treatment for varicocele.
  • It usually takes 6 – 12 months to achieve pregnancy after varicocele treatment.
  • As published in NCBI, infertility rates are highest in Africa and Central/Eastern Europe. Additionally, according to a variety of sources, rates of male infertility in North America, Australia, and Central and Eastern Europe varied from 4 5-6%, 9%, and 8-12%, respectively.


Why Choose Pristyn Care for Male Infertility Treatment?

  • Pristyn Care is a trusted and reliable healthcare provider for male infertility treatments.
  • Pristyn Care is associated with some of the top hospitals and labs across India that are equipped with state-of-the-art facilities required to perform all tests and treatments for male infertility.
  • Urologists and infertility specialists at Pristyn Care do a thorough consultation in the case of every patient to understand the health complication and their expectation from the treatment and then determine the best line of treatment method for him/ them.
  • Infertility is more than just a physical health complication. It can bring along emotional, financial, and psychological struggles. Our doctors are empathetic towards the condition of every patient. They go beyond providing just the medical treatment. They make sure to be there for the patient throughout and after the treatment.
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